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KMID : 0603520040090040237
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Journal of Korean Association of Cancer Prevention
2004 Volume.9 No. 4 p.237 ~ p.243
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Role of Relish, a Drosophila NF-κB Protein, in Response to UV Irradiation
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Kim Young-Shin
Yang Dong-Jin
Nam Hyuck-Jin
Park So-Young
Kim Byeong-Gee
Yoo Mi-Ae
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Abstract
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NF-κB has emerged as a central component of the cellular signaling machinery that serves as an important regulatory role in inflammation, immunity, and oncogenesis. During UV exposure, a positive correlation between NF-κB/Rel activation and its translocation to the nucleus, and phosphorylation and degradation of I-κB protein have been known in mammal. While the mechanisms involved in NF-κB activation upon inflammatory response are well documented both in flies and mammals, little is known that Drosophila NF-κB plays any functional roles in UV irradiation. In this study, using a null mutant of Relish, Drosophila NF-κB, we investigated a role of Drosophila NF-κB in response to UV irradiation. We found UV-induced NF-κB activation through gel mobility shift assay with the κB binding sequences of defensin promoter region. Relish null mutant larvae were more sensitive to UV-induced pigmentation, immunosuppression and apoptosis of hemocytes than wild-type. These results suggest that Drosophila NF-κB protein is involved in immune response and serves as an anti-apoptosis factor against UV irradiation.
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KEYWORD
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NF-κB, Relish, UV, Drosophila
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